The HIV-AIDS pandemic has been a challenge for professionals because of its bio-psycho-social repercussions. For this reason, since the 1990s, our team has developed different research lines. In terms of prevention, it has been studied the level of information, the attitudes and the main risk behaviors in general population. An analysis has been made of the dispositional variables that could favor risk in different groups (young people, women, commercial sex workers, etc.), and the evolution in the last decades of sexual risk behaviors and the realization of antibody detection tests. In this same field, the differential effectiveness of several prevention components and the role of the personal characteristics of program participants when modulating their  effectiveness have been also evaluated. We have developed different prevention programs and evaluated their efficacy. In terms of psychosocial care, it has been analyzed the factors that could modulate the quality of life of infected people. It has also been evaluated the effectiveness of a multicomponent program aimed at improving their well-being, including aspects such as treatment adherence or social support. In this context, studies have also been developed to evaluate the solidarity and stigma associated with the disease.